Perioperative Brain Health

Brain monitoring built for the full surgical journey.

Drug-aware brain monitoring across pre-op baseline, intra-op depth, and post-op recovery. One system for the full surgical journey.

Clinical Partners
Research Validation
0Integrated platform
0Perioperative phases
0Major anesthesia agents
0Tier‑1 clinical partners
510(k)FDA pathway
The Problem

A silent epidemic
at the operating table.

Anesthesia is safe at the cardiopulmonary level. For the aging brain, it remains largely unmonitored — and for patients with undiagnosed cognitive vulnerability, it can accelerate decline.

1 in 5 American adults has preclinical Alzheimer’s. Most don’t know it — and anesthesia may be the trigger.

0%
Cognitive Impact

of older surgical patients develop delirium or cognitive decline after anesthesia.

$0B
Annual Cost Burden

added each year to the U.S. healthcare system from perioperative brain complications.

0M
At-Risk Americans

live with preclinical Alzheimer’s — undetected before they go under anesthesia.

Sources: Cognitive decline · Cost effectiveness for delirium · Brain-function-monitoring · Alzheimer’s disease · MIT Brain Health Study

The Platform

Three phases. One system.

One device. One dataset. Continuous monitoring from pre-op baseline through post-op recovery.
01 · Pre-operative

Cognitive baseline.

ML-driven cognitive screening establishes a brain-health baseline and flags preclinical vulnerability before the first drug is given.

MoCA · Mini-Cog · Passive EEG
02 · Intra-operative

Drug-aware guidance.

Real-time multi-region EEG and AEP, interpreted by proprietary ML, delivering depth-of-sedation monitoring that stays reliable across all major anesthesia agents and mixed-drug sedation.

EEG + AEP · Real-time · All major anesthesia agents
03 · Post-operative

Recovery prediction.

Continuous post-anesthesia monitoring detects emergent delirium and forecasts recovery trajectory before discharge.

Delirium detection · Recovery trajectory
Why KBO

Built on how the brain actually works.

Existing depth monitors measure local electrical activity at the forehead and compress it to a single number. KBO measures how signals propagate between brain regions — the dimension that actually tracks consciousness and drug response.
01
A platform, not a depth monitor.
The first system to span pre-op cognitive screening, intra-op depth, and post-op delirium detection. One device. One dataset.
02
Drug-aware by design.
Legacy monitors fail on ketamine, dexmedetomidine, and mixed-agent sedation. KBO’s algorithms recognize drug-specific neural signatures and adjust automatically.
03
Reimbursable pathway through existing codes.
KBO’s cognitive and delirium outputs are designed to align with existing CPT codes, creating a potential reimbursable pathway that could shift brain monitoring from absorbed cost toward a revenue-generating workflow.
04
Designed for the full care continuum.
Dental sedation, GI endoscopy, office-based anesthesia, ambulatory surgery — the fastest-growing surgical settings have never had brain monitoring built for them. KBO is.
Clinical Evidence

Real data.
Tier 1 sites.

KBO’s validation strategy is a prospective, multi-site clinical research program generating a proprietary perioperative dataset unavailable to any competitor. Publications are in the pipeline.
  • UC Davis Health
    Department of Anesthesiology · Lead clinical partner
  • McLeod Health
    Multi-site data collection · Cardiothoracic and outpatient surgery
  • MIT Validation Study
    Independent validation of KBO’s underlying science
    Published
Study at a glance
≥0.90
AUROC target for drug-aware depth monitoring
400
Target study participants across sites
4
Drug classes: propofol, sevoflurane, ketamine, dexmedetomidine
3
Peer-reviewed manuscripts in preparation (ASA-targeted)
Request full clinical briefing →
Regulatory
FDA 510(k) pathway, submission in progress
Intellectual Property
Patents pending
Core algorithms + hardware
Non-Dilutive Pipeline
4 grants pending
NSF · ARPA-H · APSF
Manufacturing
ISO 13485 pathway
Contract manufacturing in qualification
In the News

External validation.

Independent coverage and publications validating the science behind KBO.
Leadership

Built by people who have done this before.

Clinical leadership from UC Davis and McLeod. Commercial experience from Medtronic, Philips, and Stryker. Scientific depth in cognitive neuroscience and machine learning.
KG Kevin Goehl
Kevin Goehl
Founder · CEO

11+ years in medical device sales and commercialization at Medtronic, Philips, and Stryker. Hospital relationships across 8 states. Prior startup operator.

NW Nate Weitzel, M.D.
Nate Weitzel, M.D.
Co-Founder · Clinical Chair

Professor and Chair of Anesthesiology, UC Davis Health. National leader in cardiac anesthesia and perioperative brain health. 20+ years clinical leadership.

ZZ Zhibin Zhou, M.D., Ph.D.
Zhibin Zhou, M.D., Ph.D.
Lead Scientist

Anesthesiologist and cognitive neuroscientist. Runs the UC Davis site, drives data quality, and leads biomarker discovery and algorithm translation.

RC Rocky Cagle, DNAP, CRNA
Rocky Cagle, DNAP, CRNA
Clinical Lead, McLeod

Chief of Anesthesia at McLeod Health. Leads multi-site data collection and clinical protocol design. Former ICU nurse at Johns Hopkins.

Strategic Advisors
GF Greg Fettig
Greg Fettig
Patent Counsel · FisherBroyles · 20+ years medtech IP strategy and portfolio building
VR Virginia Richards, Ph.D.
Virginia Richards, Ph.D.
Cognitive Sciences · UC Irvine · Auditory perception expert guiding KBO’s AEP design
RT Ryan Tyner, M.D.
Ryan Tyner, M.D.
Physician Executive · Optum · 20+ years in value-based care and Medicare Advantage operations
SH Stephen Hatch
Stephen Hatch
Commercial Strategy · Stryker · Medical device sales leader with expertise in orthopedics and robotic-assisted surgery
RM Reg Martin, M.D.
Reg Martin, M.D.
Clinical Advisor · Anesthesiologist · 25+ years perioperative practice with direct experience in ambulatory and surgical hospital settings
Future Partners
MR
Mike Ryan
Regulatory · Eliquent Life Sciences · Former FDA, anesthesia-device clearance strategy
TR
Triple Ring Technologies
Manufacturing · Medical device contract manufacturer specializing in patient monitoring
Get in Touch

Active seed round.

Data room and management presentation available under mutual NDA. Replies within two business days.
Investor inquiries
info@kbosystems.com
Compose email